Periodontal disease consists of chronic gingival inflammation characterized by both degradation of the periodontal connective\ntissue and alveolar bone loss. Drug therapy is used as an auxiliary treatment method in severe chronic periodontitis, aggressive\nperiodontitis, and periodontitis-associated systemic disease. Nal-P-113, a modified antimicrobial peptide, specifically replaces the\nhistidine residues of P-113 with the bulky amino acid
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